Molecular group:
Immune cells
Molecule/Cell:
Platelets
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-platelet (anti-GPIb) or platelet inhibitors (acetylsalisyllic acid (ASA) or Clopidogrel (day 1)
Lethal infection (Con):
60% (at the end of observation day 10)
Lethal infection (EG):
20% (at the end of observation day 10)
Pathology (Con):
CM (60%)
Pathology (EG):
CM (20%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Anti-platelet therapy starting 3 days p.i. did not improve survival; mice treated with ASA had ↓ number of brain T cell infiltrates compared to control (non-infected) mice
Refs:
Srivastava et al., 2008, Cell Host Microbe
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