Molecular group:
Immune cells
Molecule/Cell:
NKT cell
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 6 generations
Experimental treatment group (EG):
CD1d -/-
Lethal infection (Con):
yes
Lethal infection (EG):
80% (at the end of observation day 14)
Pathology (Con):
CM (100%)
Pathology (EG):
CM (80%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ serum IFN-g; similar serum TNF-a; ↓ proliferative response and IFN-g production by CD4+ T cells in vitro after stimulation with parasite lysate or anti-CD3 at early time-points (day 3) and similar IL-4 production
Refs:
Hansen et al., 2003, Immunity
Hyperlink: