Molecular group:
Immune cells
Molecule/Cell:
NK cells
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6-bg/+
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Beige mutation (bg/ bg) (defect in NK cell cytotoxicity)
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ in vitro NK cell cytotoxicity and similar IFN-g and TNF-a secretion by enriched NK cells
Refs:
Mohan et al., 1997, J Immunol
Hyperlink: