B cells

Molecular group: 
Immune cells
Molecule/Cell: 
B cells
Plasmodium strain: 
Plasmodium chabaudi chabaudi AS
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for 7 - 10 generations
Experimental treatment group (EG): 
m-BCR -/- (m-MT)
Lethal infection (Con): 
no
Lethal infection (EG): 
no
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Developed a chronic low parasitemia (1-10%)
Additional phenotypes (EG vs Con): 
Similar precursor frequencies of CD4+ T cells able to proliferate in response to malarial antigens; CD4+ T cells were still of a predominant IFN-g (Th1) phenotype at the later stages of infection (no switch toward a IL-4 (Th2) phenotype); parasite clearance after adoptive transfer (in the chronic phase) of B cells which restores the Th2 response
Refs: 
Langhorne et al., 1998, Proc Natl Acad Sci U S A