Molecular group:
Immune cells
Molecule/Cell:
CD4+CD25+Foxp3+ Treg cells
Plasmodium strain:
Plasmodium yoelii 17XL
pRBC infection titer:
10^4
Mouse genetic background (Con):
BALB/c
Experimental treatment group (EG):
anti-CD25 (day -3, -1 and 5)
Lethal infection (Con):
yes
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Developed 2 waves of parasitemia and cleared infection
Additional phenotypes (EG vs Con):
↑ proliferative response of splenocytes after stimulation with pRBC (in vitro)
Refs:
Hisaeda et al., 2004, Nat Med
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