CD4+CD25+Foxp3+ Treg cells

Molecular group: 
Immune cells
Molecule/Cell: 
CD4+CD25+Foxp3+ Treg cells
Plasmodium strain: 
Plasmodium chabaudi adami DS
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
BALB/c
Experimental treatment group (EG): 
anti-CD25 (day -1 and +1)
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Increased on day 7
Additional phenotypes (EG vs Con): 
Earlier death (1 day); ↑ morbidity; ↓ CD4+FOXP3-CD25+ and similar CD4+FOXP3-CD69+ and CD4-CD69+ lymphocytes in spleen; ↑ parasite-specific IFN-g and similar IL-2 response by CD4+ T cells (in vitro); ↑ IFN-g and similar IL-2 response by CD4+ T cells after stimulation with anti-CD3 (in vitro); ↑ TNF-a, IFN-g and IL-10 production by unstimulated CD90- (Thy-1-) splenocytes and ↑ IFN-g production by unstimulated CD4+ cells (in vitro) ; ↑ anemia
Refs: 
Cambos et al., 2008, Int J Parasitol