Molecular group:
Immune cells
Molecule/Cell:
CD4
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for at least 8 generations
Experimental treatment group (EG):
anti-CD4
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
No parasite clearance in 28 days
Additional phenotypes (EG vs Con):
Less severe weight loss and hypothermia; ↓ serum levels (in vivo) and production of IFN-g and TNF-a by splenocytes (in vitro); TNF-a serum levels and production by splenocytes remained elevated 4 weeks p.i.
Refs:
Franklin et al., 2007, Microbes Infect
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