Molecular group:
Immune cells
Molecule/Cell:
T cells
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^4
Mouse genetic background (Con):
BALB/c-nu/+
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Nude mice (nu/nu): no thymus thus no mature T cells
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (70%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
A less abrupt incline
Additional phenotypes (EG vs Con):
Prolonged survival (~ 2 weeks); slower progression of anemia; similar parasite-specific and total IgM titers; delayed and ↓ parasite-specific and total IgG titers; ↑ serum C3 levels; ↓ immune complexes in serum
Refs:
Finley et al., 1982, J Immunol
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