HMG-CoA reductase

Molecular group: 
Metabolic markers
Molecule/Cell: 
HMG-CoA reductase
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
5 x 10^5
Mouse genetic background (Con): 
C57BL/6
Experimental treatment group (EG): 
HMG-CoA reductase inhibitor (statins)
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (100%)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
↓ plasma IFN-g and similar plasma levels of MCP-1 5 days p.i.; similar plasma levels of IL-6 6 days p.i.; dose-dependent ↑ of TNF-a and IL-6 production by TLR2 and TLR4-stimulated peritoneal macrophages
Refs: 
Helmers et al., 2009, Am J Trop Med Hyg