IDO-1

Molecular group: 
Metabolic markers
Molecule/Cell: 
IDO-1
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Experimental treatment group (EG): 
kynurenine-3-hydroxilase inhibitor (i.p. vs p.o.)
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (60% i.p. or 75% p.o.)
Parasitemia (EG vs Con): 
Decreased (i.p.) or similar (p.o.)
Additional phenotypes (EG vs Con): 
No neurologic symptoms; prolonged survival (~ 2 weeks); ↓ brain PA (also ↓ in mice that developed fatal CM, but less pronounced); similar KA and QA levels in brain
Refs: 
Miu et al, 2009, Int J Parasitol