NOS2

Molecular group: 
Metabolic markers
Molecule/Cell: 
NOS2
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
N.I.
Mouse genetic background (Con): 
C57BL/6
Experimental treatment group (EG): 
NO donor or + NO gas
Lethal infection (Con): 
yes
Lethal infection (EG): 
20% (at the end of observation day 12)
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (20%)
Parasitemia (EG vs Con): 
similar
Additional phenotypes (EG vs Con): 
No neurological symptoms; restored cGMP brain levels; ↓ plasma IL-18, sCD40 and MMP-9; similar IL-1b, IL-6, IL-10, IFN-g and TIMP-1
Refs: 
Gramaglia et al., 2006, Nat Med