HO-1

Molecular group: 
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell: 
HO-1
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
C57BL/6
Experimental treatment group (EG): 
CO gas
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
No CM
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Protective effect was only seen with early CO treatment; 80 % reduction of BBB disruption; reduced red blood cell and leukocyte sequestration in brain microvasculature; no brain hemorrhages; ↓TNF-a, IFN-g, LT-a, ICAM-1 and VCAM-1 mRNA in brain; ↓CD8+CD69+ T cells, CD8+IFN-g+ T cells, macrophages and PMN recruitment into the brain; restored MetHb concentration; restored plasma free heme concentration to basal levels without inhibition of red blood cell lysis
Refs: 
Pamplona et al., 2007, Nat Med