HO-1

Molecular group: 
Neural or endothelial cell stress/damage/activation markers
Molecule/Cell: 
HO-1
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
C57BL/6
Experimental treatment group (EG): 
HO-1 inhibitor
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (100%)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Similar BBB breakdown, microvascular congestion and hemorrhages in brain; similar plasma free heme concentration (increased compared to uninfected C57BL/6 mice)
Refs: 
Pamplona et al., 2007, Nat Med