Bcl-2

Molecular group: 
Signal transduction and intracellular danger sensors
Molecule/Cell: 
Bcl-2
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
♀ 10^6, ♂ 5 x 10^5
Mouse genetic background (Con): 
C57BL/6
Experimental treatment group (EG): 
over-expression of bcl-2 in myeloid cells (hMRP8-Bcl-2 mice)
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (100%)
Parasitemia (EG vs Con): 
N.I.
Additional phenotypes (EG vs Con): 
Similar number of TUNEL-positive cells in the brain
Refs: 
Helmers et al., 2008, Am J Trop Med Hyg