Molecular group:
Angiogenic and coagulation factors
Molecule/Cell:
uPA receptor (uPAR, CD87)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6 x 129/Sv
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
uPAR -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (80%)
Pathology (EG):
CM (20%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (~1 week) ; ↓ thrombocytopenia; slightly ↓ platelet life span (similar to noninfected uPAR -/- mice); slightly ↑ fibrinogen half-life; ↑ splenomegaly; no ↑ in lung weight; similar TNF-a mRNA in spleen, lung and brain; similar leakage of Evans Blue in brain and lung; ↓ platelet trapping in alveolar and brain capillaries; similar PMN, macrophage and pRBC sequestration in alveolar capillaries; similar mononuclear leukocytes in brain microvasculature
Refs:
Piguet et al., 2000, Infect Immun
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