Histamine R3/R2

Molecular group: 
Leucocyte effector mechanisms and proteases
Molecule/Cell: 
Histamine R3/R2
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
H3R -/-
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
H2R inhibitor (cimetidine)
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (60%)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
↓ IFN-g and TNF-a brain mRNA expression 6 days p.i.
Refs: 
Beghdadi et al., 2009, PLoS One