Histamine R1

Molecular group: 
Leucocyte effector mechanisms and proteases
Molecule/Cell: 
Histamine R1
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6J
Experimental treatment group (EG): 
H1R inhibitor (levocetirizine)
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (80%)
Pathology (EG): 
CM (30%)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Prolonged survival (2-3 weeks) only when used prophylactic; ↓ IFN-g and TNF-a brain mRNA expression 6 days p.i.
Refs: 
Beghdadi et al., 2009, PLoS One