Caspase-12/IKK

Molecular group: 
Leucocyte effector mechanisms and proteases
Molecule/Cell: 
Caspase-12/IKK
Plasmodium strain: 
Plasmodium chabaudi AS
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for 9 generations
Experimental treatment group (EG): 
Casp12 -/- + IKK inhibitor
Lethal infection (Con): 
no
Lethal infection (EG): 
no
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Similar serum IgG2a 21 days p.i. (↓ compared to untreated infected casp12 -/- mice)
Refs: 
Labbé et al., 2010, J Immunol