Caspase-1

Molecular group: 
Leucocyte effector mechanisms and proteases
Molecule/Cell: 
Caspase-1
Plasmodium strain: 
Plasmodium chabaudi AS
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6 x 129/S2SvPas
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
Casp1 -/-
Lethal infection (Con): 
no
Lethal infection (EG): 
no
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Similar serum IFN-g, TNF-a, IL-10; similar serum IgG1 and IgG2a 21 days p.i.; ↓ serum IL-18 6-7 days p.i.; similar anemia and weight loss; similar production of IFN-g, IL-10 and IL-1b by splenocytes after stimulation with pRBCs
Refs: 
Labbé et al., 2010, J Immunol