Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
ABCA1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
DBA/1
Level of backcrossing:
Pure strain (100%)
Experimental treatment group (EG):
ABCA1 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (88%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (1-2 weeks); ↓ plasma TNF-a; ↓ ICAM-1, VCAM-1, LFA-1, CD41/CD61 and TNF-a protein in the brain; similar CD40 protein in the brain; ↓ leukocyte sequestration in brain vessels; ↓ plasma HDL cholesterol; ↓ MP production due to ↓ response to vesiculation agonists; ↓ procoagulant activity by MP
Refs:
Combes et al., 2005, Am J Pathol
Hyperlink: