FcgRIIB/TLR7

Molecular group: 
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell: 
FcgRIIB/TLR7
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
FcgRIIB-/-.yaa (SLE-susceptible), contains a duplication of TLR7
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (90%)
Pathology (EG): 
CM (10%)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Prolonged survival (~1 week); ↑ splenomegaly 7 days p.i.; ↓ postmortem brain and similar kidney weight; developped moderated kidney inflammation; ↓ number of brain microhemorrhages; ↑ serum GM-CSF and IL-10 before infection; similar levels of serum GM-CSF and ↓ IL-10, IFN-g, IL-12p70, IL-17, IL-6, MCP-1 and RANTES 5 days p.i.; splenic immune cell populations had features of a controlled chronic activation before infection that was absent in WT mice, and infection resulted in ↓ inflammatory responses compared to WT mice; similar recruitment of CD4+ and CD8+ T cells with a similar activation status in the brain
Refs: 
Waisberg et al., 2010, Proc Natl Acad Sci U S A