Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
FcgRIIB
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
FcgRIIB-/- (SLE-susceptible)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (60%)
Pathology (EG):
CM (10%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (~1 week); ↑ splenomegaly 7 days p.i.; no kidney inflammation
Refs:
Waisberg et al., 2010, Proc Natl Acad Sci U S A
Hyperlink: