Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
FcgRIIB
Plasmodium strain:
Plasmodium chabaudi chabaudi
pRBC infection titer:
10^5 - 5 x 10^6
Mouse genetic background (Con):
BALB/c
Level of backcrossing:
Backcrossed for at least 8 generations
Experimental treatment group (EG):
FcgRIIB-/- (SLE-susceptible)
Lethal infection (Con):
no
Lethal infection (EG):
ni
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Decreased peak and more rapid clearance
Additional phenotypes (EG vs Con):
↓ anemia and hypothermia; ↑ expression of CD86, production of TNF and phagocytosis of iRBCs by macrophages in vitro; ↑ antimalarial IgG
Refs:
Clatworthy et al., 2007, Proc Natl Acad Sci U S A
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