MyD88

Molecular group: 
Signal transduction and intracellular danger sensors
Molecule/Cell: 
MyD88
Plasmodium strain: 
Plasmodium chabaudi chabaudi AS
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for at least 8 generations
Experimental treatment group (EG): 
MyD88 -/-
Lethal infection (Con): 
no
Lethal infection (EG): 
no
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Less severe hypothermia and no weight loss; resistant to a secondary infection; ↑ IgG1 and similar IgG2a levels; ↓ TNF-a and IFN-g and similar MCP-1 production by splenocytes (in vitro) and in the serum (in vivo) 8 days p.i.; ↓ production of IL-1a, IL-6 (only by DC), TNF-a and IL-12 by CD11b+ macrophages and CD11c+ DC cells in spleen; similar expression of CD40 and CD86 by DC (similar maturation status), ↓ number of ab TCR+, CD4+ and NK cells producing IFN-g and TNF-a; ↓ % op CD25+ and CD69+ CD4+ T cells
Refs: 
Franklin et al., 2007, Microbes Infect