Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
TLR9
Plasmodium strain:
Plasmodium yoelii 17XL
pRBC infection titer:
1 - 1,5 x 10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for at least 15 generations
Experimental treatment group (EG):
TLR9 -/-
Lethal infection (Con):
94%
Lethal infection (EG):
50%
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Variable
Additional phenotypes (EG vs Con):
Similar CD4+CD25+Foxp3+ (Treg) cells in spleen; no activation of Treg cells; ↑ CD62LlowCD69high and IFN-g+ CD4+ cells in spleen; CD4+ cells proliferated in response to pRBC
Refs:
Hisaeda et al., 2008, J Immunol
Hyperlink: