Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
TLR2/4/9
Plasmodium strain:
Plasmodium yoelii 17XNL
pRBC infection titer:
5 x 10^6
Mouse genetic background (Con):
N.I.
Level of backcrossing:
N.I.
Experimental treatment group (EG):
TLR2/4/9 -/-
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar serum IL-12p40 and IL-18 6 days p.i.; ↑ number of CD62Llow+CD4+ and CD69+CD4+ T cells in the spleen 6 days p.i.; no difference in [3H]thymidine uptake upon stimulation of splenocytes with anti-CD3; similar production of IL-12p40, IFN-g and ↑ IL-10 after stimulation of splenocytes isolated 6 days p.i. with anti-CD3
Refs:
Cramer et al., 2008, Microbes Infect
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