Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
TLR2
Plasmodium strain:
Plasmodium chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
TLR2 -/-
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar up-regulation of CD40, CD86 and MHC class II, similar production of TNF-a and IL-12p70, degradation of IkB-a and translocation of NF-kB to the nucleus after incubation of TLR2 -/- DCs with P. berghei or P. chabaudi schizonts; Similar increase of CD40, CD80 and CD86 on splenic DCs isolated from P. berghei-infected mice 6 days p.i. and P. chabaudi-infected mice 7 days p.i.
Refs:
Seixas et al., 2009, Eur J Immunol
Hyperlink: