Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
TLR2
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 8 generations
Experimental treatment group (EG):
TLR2 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (90%)
Pathology (EG):
CM (45%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar serum IL-12p40, IFN-g and TNF-a; ↓ hemozoin clusters in brain vessels
Refs:
Coban et al., 2007, Int Immunol
Hyperlink: