Molecular group:
Signal transduction and intracellular danger sensors
Molecule/Cell:
Nlrp3
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
N.I.
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Nlrp3 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Slightly delayed death (~ 2 days); similar serum levels of IFN-g, IL-10, TNF, IL-1b and IL-6; similar mRNA expression of IP-10, P-selectin and ICAM-1 in the brain; similar up-regulation of CD69 and down-regulation of CD62L on T-cells; similar frequency of IFN-g-producing CD4+ T cells
Refs:
Reimer et al., 2010, Eur J Immunol
Hyperlink: