Molecular group:
Adhesion molecules
Molecule/Cell:
CD54 (ICAM-1)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
ICAM-1-/-
Lethal infection (Con):
yes
Lethal infection (EG):
33% (at the end of observation day 14)
Pathology (Con):
CM (100%)
Pathology (EG):
CM (33%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (1-3 weeks); similar leukocyte rolling and adhesion in brain microvasculature;
Refs:
Li et al., 2003, J Investig Med
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