CD11a/CD18 (LFA-1)

Molecular group: 
Adhesion molecules
Molecule/Cell: 
CD11a/CD18 (LFA-1)
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
CBA/Ca
Experimental treatment group (EG): 
anti-CD11a
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (85-90%)
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Prolonged survival (2-3 weeks: late as well as early treatment); no neurological symptoms; no vascular permeability in brain and ↓vascular permeability in lungs; ↓ mononuclear cell sequestration in brain and lungs; ↓ (brain) and similar (lungs) platelet accumulation; similar microhemorrhages in the brain; ↓ myeloperoxidase activity (neutrophil enzyme) in lungs; similar liver pathology; ↓injected aggregated albumin localization in brain and lungs
Refs: 
Senaldi et al., 1994, Infect Immun