b2 integrin (CD18)

Molecular group: 
Adhesion molecules
Molecule/Cell: 
b2 integrin (CD18)
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^4
Mouse genetic background (Con): 
C57BL/6J
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
CD18 -/-
Lethal infection (Con): 
N.I.
Lethal infection (EG): 
N.I.
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
N.I.
Additional phenotypes (EG vs Con): 
↑ LN cellularity; similar splenomegaly; no significant apoptosis in white pulp (spleen) and LN
Refs: 
Piguet et al. 2001, Dev Immunol