Molecular group:
Chemokines and receptors
Molecule/Cell:
CCR2
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6 x 129/Ola
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
CCR2 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (70%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ macrophages, CD4+ T cell, PMN and similar CD8+ T cells in the brain; depletion of CD8+ T cells, but not of CD4+ T cells or PMNs, rescued these mice from CM
Refs:
Belnoue et al., 2003, Infect Immun
Hyperlink: