Molecular group:
Chemokines and receptors
Molecule/Cell:
CXCL4 (PF-4)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for more than 10 generations
Experimental treatment group (EG):
PF-4 -/-
Lethal infection (Con):
N.I.
Lethal infection (EG):
N.I.
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
↓ KLF4 expression in monocytes; ↓ monocytes in brain during CM
Refs:
Srivastava et al., 2010, PLoS ONE
Hyperlink: