Molecular group:
Cytokines and receptors
Molecule/Cell:
TGF-b
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
5 x 10^4
Mouse genetic background (Con):
C57BL/10 Sn Slc
Experimental treatment group (EG):
rTGF-b
Lethal infection (Con):
no
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
No decline and increased
Additional phenotypes (EG vs Con):
↓ serum IFN-g (day 7) and NO (day 10); abrogated increase of Ly6A/E on CD4+ T cells and abrogated increase of MHC-II on CD11b+ cells in spleen
Refs:
Tsutsui et al., 1999, Infect Immun
Hyperlink: