TGF-b/IL-10R

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
TGF-b/IL-10R
Plasmodium strain: 
Plasmodium yoelii 17XL
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
C57BL/6
Experimental treatment group (EG): 
anti-TGF-b + anti-IL-10R
Lethal infection (Con): 
yes
Lethal infection (EG): 
60% (at the end of observation day 34)
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Complete parasite clearance
Additional phenotypes (EG vs Con): 
↑ plasma TNF-a and slightly ↑ plasma IFN-g
Refs: 
Omer et al., 2003, J Immunol