Molecular group:
Cytokines and receptors
Molecule/Cell:
TGF-b
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^4
Mouse genetic background (Con):
BALB/c
Experimental treatment group (EG):
anti-TGF-b
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Earlier onset
Additional phenotypes (EG vs Con):
Earlier death (~ 1 week); ↑ serum TNF-a and similar IFN-g, IL-4 and IL-10
Refs:
Omer et al., 1998, J Exp Med
Hyperlink: