Molecular group:
Cytokines and receptors
Molecule/Cell:
TNFR2
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6 x 129
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
TNFR2 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (90%)
Pathology (EG):
CM (10%)
Parasitemia (EG vs Con):
similar
Additional phenotypes (EG vs Con):
Prolonged survival (weeks); no neurological symptoms; similar serum IFN-g, TNF-a and sTNFR1; no ↑ in ICAM-1 expression on brain endothelial cells; no sequestration of leukocytes in the brain; no induction of ICAM-1 expression in MVEC after stimulation with soluble or membrane-bound mTNF or membrane-bound hTNF
Refs:
Lucas et al., 1997, Eur J Immun
Hyperlink: