TNFR1

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
TNFR1
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
5 x 10^4
Mouse genetic background (Con): 
C57BL/6J
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
TNFR1 -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM
Pathology (EG): 
CM
Parasitemia (EG vs Con): 
similar
Additional phenotypes (EG vs Con): 
Similar TNF-a, CD40 and ICAM-1 in brain; ↓ vascular leakage in brain and lung; similar BBB breakdown, macrophage accumulation in brain, hyperglycemia, insulin resistance, hypothermia, edema, thrombocytopenia and lung weight; enlarged basement membrane of brain capillaries in KO mice
Refs: 
Piguet et al., 2002, Lab Invest