TNF-a/ IFN-g

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
TNF-a/ IFN-g
Plasmodium strain: 
Plasmodium chabaudi chabaudi AS
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Experimental treatment group (EG): 
anti-TNF-a + anti-IFN-g
Lethal infection (Con): 
no
Lethal infection (EG): 
no
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Increased peak
Additional phenotypes (EG vs Con): 
↓ iNOS mRNA expression in spleen 7 days p.i.; ↓ NO3- levels in serum (synergy) 7 days p.i.; ↓ spleen weight 7 days p.i.
Refs: 
Jacobs et al. 1996, Infect Immun