Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
DBA/2
Experimental treatment group (EG):
anti-TNF-a
Lethal infection (Con):
75%
Lethal infection (EG):
25%
Pathology (Con):
Liver pathology and severe anemia
Pathology (EG):
No liverpathology
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ plasma AST, ↓ liver portal and central lobular vein necrosis, inhibition of hepatocyte programmed cell death; only the combination of free heme and TNF-a induced free radicals, lipid peroxidation products and apoptosis in hepatocytes in an in vitro assay which was reduced after treatment with anti-oxidantia (BHA, NAC) or by transduction of hepatocytes with an HO-1 expressing adenovirus
Refs:
Seixas et al., 2009, Proc Natl Acad Sci U S A
Hyperlink: