Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
DBA/2
Experimental treatment group (EG):
anti-TNF-a
Lethal infection (Con):
70%
Lethal infection (EG):
20%
Pathology (Con):
Liver pathology
Pathology (EG):
No liverpathology
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ liver apoptosis and necrosis; ↓ plasma AST and ALT; similar blood hemoglobin concentration
Refs:
Seixas et al., 2008, Parasitology
Hyperlink: