Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/Ca
Experimental treatment group (EG):
anti-TNF-a
Lethal infection (Con):
yes
Lethal infection (EG):
N.I.
Pathology (Con):
CM (80%)
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
↓ serum IL-6
Refs:
Grau et al., 1990, J Exp Med
Hyperlink: