Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a/ LT-a
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
TNF-a -/- x LT-a -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (days); no neurological symptoms; ↓ serum NO3- and IFN-g; ↓ ICAM-1 and CR3+ leukocytes in the brain
Refs:
Engwerda et al., 2002, J Exp Med
Hyperlink: