TNF-a

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
TNF-a
Plasmodium strain: 
Plasmodium berghei (N.I.)
pRBC infection titer: 
10^4
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for more than 10 generations
Experimental treatment group (EG): 
TNF-a -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
N.I.
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
N.I.
Additional phenotypes (EG vs Con): 
Similar number of CD11c+ DC in the spleen; ↓ expression of MHC II, CD80 and CD86 by splenic CD11c+ DC; CD11c+ DC were better at initiation of proliferation of OTII T cells; ↑ IL-12 secreting DC in the spleen
Refs: 
Wykes et al., 2007, J Immunol