TNF-a

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
TNF-a
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^4
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
TNF-a -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (100%)
Parasitemia (EG vs Con): 
similar
Additional phenotypes (EG vs Con): 
↓ serum NO3-; similar serum IFN-g, ↓ ICAM-1 and ↓ CR3+ leukocytes in the brain
Refs: 
Engwerda et al., 2002, J Exp Med