Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF
Plasmodium strain:
Plasmodium chabaudi adami 408XZ
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6J
Level of backcrossing:
Backcrossed for 5 generations
Experimental treatment group (EG):
TNF -/-
Lethal infection (Con):
29%
Lethal infection (EG):
70%
Pathology (Con):
Anemia
Pathology (EG):
Anemia
Parasitemia (EG vs Con):
Increased peak and increased recrudescences
Additional phenotypes (EG vs Con):
↓ Hb levels on d4, d12 and d16 p.i.; similar blood glucose and lactate levels except on d7 p.i.; ↓ body temperature on d7, d12, d16 and d25 p.i.; similar body weights except on d4 p.i.
Refs:
Hernandez-Valladares et al., 2006, Exp Parasitol
Hyperlink: