Molecular group:
Cytokines and receptors
Molecule/Cell:
SOCS1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for more than 10 generations
Experimental treatment group (EG):
SOCS1 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (80%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (2-3 days); no neurologic symptoms; lympocytic infiltrates in muscle and lungs; ↓ splenic cellularity; ↓CD4:CD8 T cell ratio compared to WT mice, but similar as in uninfected KO mice
Refs:
Bullen et al., 2003, Parasite Immunol
Hyperlink: