Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-g
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6J
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IFN-g -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
no
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
No neurologic symptoms; ↑ levels (normal values) of [31P]-containing metabolites (phosphocreatinine (PCr), and PCr:PME), ↑ levels of b-ATP, similar levels (normal values) of phosphomonoesters (PME), and ↓ levels (normal values) of inorganic phosphate (Pi), Pi:b-ATP and Pi:PCr in brain 6-7 days p.i.; normal lactate, glutamate, GABA, aspartate, alanine, NAA and glutamine metabolite pool sizes in brain (compared with uninfected IFN-g -/- mice); no ↓ brain net flux of 13C from D-[1-13C]glucose into metabolic intermediates associated with Krebs cycle (normal compared to uninfected IFN-g -/- mice), except for Ala C3 which did not change upon infection
Refs:
Parekh et al., 2006, Int J Parasitol
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