Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-12
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
rIL-12
Lethal infection (Con):
yes
Lethal infection (EG):
20% (at the end of observation day 23)
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed onset and decreased peak
Additional phenotypes (EG vs Con):
Prolonged survival (1-2 weeks); ↑ NOS2 mRNA expression in brain 11 days p.i., in kidneys 4 days p.i. and in liver and spleen; ↑ NO2- and IFN-g production by ConA stimulated spleen cells and in serum; ↑ IFN-g mRNA expression in liver, spleen and kidney; ↑ liver pathology; ↓ IL-10 and similar TNF-a mRNA in spleen; ↑ NOS2 and similar IFN-g in brain and spleen
Refs:
Tan et al., 1999, Infect Immun
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